Optimum Therapeutics, LLC


Publications





1. Jang, S. H., Wientjes, M.G., Lu, D., and Au, J.L. Drug delivery and transport to solid tumors. Pharmaceutical Res., 20 (9):1337-50, 2003.


2. Lu, Ze, Yeh, T.K., Tsai, M., Au, J.L.-S., and Wientjes, M.G. Paclitaxel-loaded gelatin nanoparticles for intravesical bladder cancer therapy. Clin. Cancer Res., 10:7677-84, 2004.


3. Yeh, T.K., Lu, Z., Au, J.L.-S. and Wientjes, M.G. Formulating paclitaxel in nanoparticles alters its disposition. Pharmaceutical Res., 22: 867-874, 2005.


4. Lu, Z., Wientjes, T.S. and Au, J.L.-S. Nontoxic suramin treatments enhance docetaxel activity in chemotherapy-pretreated non-small cell lung xenograft tumors. Pharmaceutical Res., 22: 1069-1078, 2005.


5. Xin, Y., Lyness, G., Chen, D., Song, S., Wientjes, M.G., and Au, J.L. Low dose suramin as a chemosensitizer of bladder cancer to mmc. J. Urol., 174:322-7, 2005.


6. Wang, J., Lu, Z., and Au, J.L.-S. Protection against chemotherapy-induced alopecia. Pharmaceutical Res., 23 (11): 2505-2514, 2006.


7. Tsai, M., Lu, Z., Wang, J., Yeh, T.-K., Wientjes, M.G., and Au, J.L.-S. Effects of carrier on disposition and antitumor activity of intraperitoneal paclitaxel. Pharmaceutical Res., 24 (9): 1691-1701, 2007.


8. Lu, D., Wientjes, M.G., Lu, Z., and Au, J.L-S. Tumor Priming Enhances Delivery and Efficacy of Nanomedicines, J. Pharmacol. Exp. Ther., 322(1):80-8, 2007.


9. Lu, Z., Tsai, M., Lu, D., Wang, J., Wientjes, M.G., and Au, J.L.-S. Tumor penetrating microparticles for intraperitoneal therapy of ovarian cancer. J. Pharmacol. Exp. Ther., 327(3):673-682, 2008.


10. Wang, J., Lu, Z., Wientjes, M.G., and Au, J.L.-S. Delivery of siRNA Therapeutics: Barriers and Carriers. AAPS J., 12:492-503, 2010.


11. Lu, Z., Wang, J., Wientjes, M.G., and Au, J.L-S. Intraperitoneal therapy for peritoneal cancer. Future Oncology, 6:1625-41, 2010. 12. Au, J.L. and Wientjes, M.G. Combination intravesical hyperthermia and chemotherapy for bladder cancer. Oncology (Williston. Park), 24:1155-1160, 2010.


13. Lu, Z., Yeh, T.K., Wang, J., Chen, L., Lyness, G., Xin, Y., Wientjes, M.G., Bergdall, V., Couto, G., Alvarez-Berger, F., Kosarek, C.E., and Au, J.L-S. Paclitaxel gelatin nanoparticles for intravesical bladder cancer therapy. J. Urol., 185:1478-1483, 2011.


14. Li, Y., Wang, J., Wientjes, M.G., and Au, J.L-S. Delivery of nanomedicines to extracellular and intracellular compartments of a solid tumor. Adv. Drug Deliv. Rev., 64:29-39, 2012.


15. Wong, H.L., Shen, Z., Lu, Z., Wientjes, M.G., and Au, J.L-S. Paclitaxel tumor-priming enhances siRNA delivery and transfection in 3-dimensional tumor cultures. Mol. Pharm., 8:833-840, 2011. PMCID: PMC3109178


16. Li, Y., Wang, J., Gao, Y., Zhu, J., Wientjes, M.G., Au, J.L-S. Relationships between Liposome Properties, Cell Membrane Binding, Intracellular Processing, and Intracellular Bioavailability. AAPS J. 13:585-597, 2011. PMCID: PMC3231863


17. Wang, J., Lu, Z., Gao, Y., Wientjes, M.G., Au, J.L.-S. Improving delivery and efficacy of nanomedicines in solid tumors: Role of tumor priming. Nanomedicine (Lond). 6:1605-1620, 2011. PMCID: PMC3655409


18. Gao, Y., Li, M., Chen, B., Shen, Z., Guo, P., Wientjes, M.G., and Au, J.L. Predictive models of diffusive nanoparticle transport in 3-dimensional tumor cell spheroids. AAPS J., 2013.


19. Wang J, Lu Z, Yeung BZ, Wientjes MG, Cole DJ, Au JL. Tumor priming enhances siRNA delivery and transfection in intraperitoneal tumors. J Control Release. 178:79-85, 2014. PMCID: PMC3994124.


20. Wang J, Lu Z, Wang J, Cui M, Yeung BZ, Cole DJ, Wientjes MG, Au JL. Paclitaxel tumor priming promotes delivery and transfection of intravenous lipid-siRNA in pancreatic tumors. J Control Release. 216:103-10, 2015. PMCID: PMC4582943.



Abstracts





1. Danny Chen, SaeHeum Song, M. Guillaume Wientjes, TengKuang Yeh, Liang Zhao, Jie Wang (Presenter), Migue Villalona-Calero, Greg Otterson, Rhonda Jenson, Anthony J. Murgo, Jessie L-S Au. Low dose suramin as a chemosensitizer in patients: pharmacokinetics, identification and validation of a dosing nomogram. Proceedings of the AACR, Vol. 46, abstract #3990, 2005.


2. Leijun Hu, Liang Zhao, Danny Chen, Xiao Hu, Jie Wang, Jessie L-S. Au, M. Guillaume Wientjes. Physiology based pharmacokinetic study on suramin. Proceedings of the AACR, Vol. 46, abstract #3991, 2005.


3. Ze Lu, Max Tsai, Audrie L-L. Wientjes, Andrea Miller, Jie Wang, Greg Lyness, and Jessie L.-S. Au. Tumor priming microparticles for intraperitoneal therapy of pancreatic cancer. Proceedings of the AACR, Vol. 47, abstract #3074, 2006.


4. Jie Wang, Ze Lu, M. Guillaume Wientjes, and Jessie L.-S. Au. Pharmacodynamic endpoints of chemotherapy-induced alopecia. The AAPS Journal, Vol. 8, No.S2, abstract#T2027, 2006.


5. Jie Wang, Yan Xin, Ling Chen, Dan Lu, M Guillaume Wientjes, Bruce J. Dolnick, Ree Dolnick, and Jessie L-S Au. Improving the stability and efficacy of rTS mimetic OHL. Proceedings of the AACR, Vol. 48, abstract #3909, 2007.


6. Jie Wang, Ling Chen, Ze Lu, Bruce J. Dolnick, Ree Dolnick, M Guillaume Wientjes, and Jessie L-S Au. Nanoparticulate formulation of rTS mimetic OHL improves drug stability and anticancer efficacy. The AAPS Journal, Vol. 9, No. S2, abstract T3269, 2007.


7. M. Guillaume Wientjes, Leijun Hu, Xiao Hu, Yan Xin, Jing Li, Danny Chen, Liang Zhao, Jie Wang, and Jessie L.-S. Au Physiologically based pharmacokinetics of suramin, a chemosensitizer and prototype large negatively charged molecule. The AAPS Journal, Vol. 9, No. S2, abstract w4443, 2007.


8. Ze Lu, Max Tsai, Dan Lu, Jie Wang, M. Guillaume Wientjes, and Jessie L-S Au. Tumor priming microparticles for intraperitoneal therapy of ovarian cancer. The AAPS Journal, Vol. 9, No. S2., abstract T3304, 2007.


9. Jing Li, Tong Shen, Jie Wang, Jessie L-S Au, M. Guillaume Wientjes. Nontoxic doses of suramin enhances chemotherapy in pancreatic xenograft tumors. Proceedings of the AACR, Vol. 49, abstract #4777, 2008.


10. Wang, J., Lu, Z., Cui, M., Dorsten, J., Wientjes, M.G., and Au, J.L. Tumor penetrating microparticles enhances siRNA delivery and expression in pancreatic cancer. AAPS J., 12 (S2), 2070, 2010.​



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